I-Sodium Stearyl Fumarate (SSF) Pharmaceutical Lubricant | Ukuhambelana okuphezulu kwe-API, Enye indlela kwi-Magnesium Stearate, i-GMP Grade

I-Sodium Stearyl Fumarate (SSF) yethu sisithambisi samayeza esicocekileyo kakhulu esenzelwe ngokukodwa iipilisi kunye neekhaphu. Ngokungafaniyo ne-magnesium stearate, inika ukuhambelana okuhle kwe-API, ukomelela xa itshizwa kakhulu, kwaye ayinampembelelo imbi kwi-bioavailability.Sisithambisi esihlala emanzini, esinganyibilikiyo kakhulu esibonelela ngobunzima obuphezulu bethebhulethi ngamandla alinganayo okucinezelwa kwaye sinciphise impembelelo kwixesha lokuqhekeka.. Ihambelana ne-USP-NF, EP, kunye ne-JP pharmacopoeias kunye nobhaliso lwe-CDE (F20190000009) kunye nenkxaso ye-DMF (38822). Inqanaba lokusetyenziswa elicetyiswayo: 0.5-3% w/w. Ilungele ukucinezelwa ngqo ngesantya esiphezulu, iithebhulethi ezikhupha umoya, kunye neefomyula ezinee-API ezingahambelaniyo

Qhagamshelana nathi

Iinkcukacha zeMveliso

Ibanga leMithi iSodium Stearyl Fumarate (SSF)

Isishwankathelo seMveliso

I-Sodium Stearyl Fumarate (SSF) sisithambisi seyeza esisebenza kakuhle esaziwa ngokubanzi njengendlela engcono kunezithambisi zemveli ezifana ne-magnesium stearate kunye ne-talc.Yityuwa yesodium ye-stearyl fumaric acid, ebonakala njengomgubo ocolekileyo omhlophe ukuya komhlophe oneempawu ze-amphiphilic ezivumela ukuthambisa okusebenzayo kwimida yeepilisi kunye neekhaphu..

Ubume beMveliso:

Igama leKhemikhali:I-Sodium Stearyl Fumarate
Inombolo ye-CAS:4070-80-8
Inombolo yoBhaliso lwe-CDE:F20190000009
Inombolo ye-DMF:38822
Ukuthobela i-Pharmacopoeia:I-USP-NF, i-EP, i-JP
Ifomula yeMolekyuli:C22H39NaO4
Ubunzima beemolekyuli:390.53 g/mol

Iimpawu eziphambili kunye neenzuzo

1. Ukuhambelana kwe-API ePhakamileyo

Isombulula iingxaki zokuhambelana ezihlala zidibana ne-magnesium stearate
Ukungahambisani kwe-API okuxeliweyo kunye ne-magnesium stearate kuquka: i-Azathioprine, i-Cefaclor, i-Cilazapril, i-Clopidogrel, i-Diclofenac, i-Ibuprofen, i-Omeprazole, kunye nezinye ezininzi
Ilungele iifomyula apho ukungahambelani kweekhemikhali kuyingxaki

2. Ukuqina ukuya ekuthambiseni kakhulu

Ngokungafaniyo ne-magnesium stearate, i-SSF igcina ukusebenza kwayo nokuba ixesha elide lokuxuba liyancipha.
Inika ubulukhuni bethebhulethi kunye nokuqhekeka kwayo ngaphandle kwemiphumo "yokuthambisa kakhulu"

3. Iimpawu zeTablethi eziphuculweyo

Ubulukhuni obuphezulungamandla oxinzelelo alinganayo xa kuthelekiswa nezinye izinto zokuthambisa
Impembelelo encinci kwixesha lokuqhekeka- igcina ithebhulethi iqhekeka ngokukhawuleza
Akukho mpembelelo imbi kwi-bioavailability- kuqinisekisa ukuba iiprofayili zokukhululwa kweziyobisi zihlala zinjalo

4. Indalo ethanda amanzi kunye nenyibilikayo kancinci

I-lubricant enyibilikayo emanzini – 0.5 mg/100 mL kwi-25°C, inyuke iye kwi-20 g/100 mL kwi-90°C
Isiphumo sisiphumo sentsalela ephantsi kwisisombululo, nto leyo eyenza ukuba sibe sifanelekileyoiipilisi ezikhupha umoya
Iphucula iiprofayili zokunyibilika kwee-API ezinganyibilikiyo kakuhle

5. Iipropati Ezintle Zomzimba