I-Carboxymethylcellulose Calcium (CMC-Ca) Superdisintegrant | Amandla aphezulu okudumba okuKhawuleza ukuQothuka kweThebhulethi | I-USP/EP/ChP Compliant

I-Carboxymethylcellulose Calcium yethu (iCarmellose Calcium, i-CMC-Ca) sisithako samayeza esicocekileyo kakhulu esisebenza njengesinyibilikisi, isihlanganisi, kunye nesinyibilikisi esisebenzayo kwiifom zedosi eqinileyo yomlomo.Yityuwa yecalcium ye-carboxymethylcellulose, ebonakala njengomgubo omhlophe ukuya komhlophe oxutyiweyo onganyibilikiyo emanzini kodwa ngokukhawuleza uvuthuluka ukuya kutsho kumthamo wayo wokuqala xa udibana nemithombo yamanzi.Le ndlela ikhethekileyo yokudumba iqinisekisa ukubola ngokukhawuleza kwethebhulethi kunye nokuphuculwa kokunyibilika kwamayeza. Iingenelo eziphambili ziquka: ukungabikho komxholo wesodium (ofanelekileyo kwizigulane ezinentliziyo kunye nezithintelwe yisodium), ukucinezeleka okugqwesileyo, kunye nokuhambelana neenkqubo zokucinezelwa ngokuthe ngqo kunye neenkqubo zokuxozwa okumanzi . Ihambelana ne-USP-NF, EP, JP, kunye ne-ChP pharmacopoeias kunye ne-CDE registration F20230000328. Inqanaba eliqhelekileyo lokusetyenziswa: 0.5-15% w/w.

Qhagamshelana nathi

Iinkcukacha zeMveliso

Ibanga leMithi iCarboxymethylcellulose Calcium (iCarmellose Calcium, iCMC-Ca)

Isishwankathelo seMveliso

I-Carboxymethylcellulose I-Calcium yityuwa ye-calcium ye-polycarboxymethyl ether ye-celluloseSisithako samayeza esisebenza ngeendlela ezininzi esisetyenziswa kakhulu njengesinyibilikisi, isihlanganisi, kunye nesinyibilikisi kwiifom zedosi eqinileyo yomlomo kuquka iipilisi kunye neekhaphu Ngokungafaniyo ne-sodium, ityuwa ye-calcium inika ithuba lokwenziwa kwe-sodium-free, okwenza ukuba ifaneleke ngakumbi kubantu abaneengxaki zentliziyo kunye ne-sodium..

Ubume beMveliso:

Igama leKhemikhali:I-Carboxymethylcellulose I-Calcium / iCarmelose I-Calcium
Inombolo ye-CAS:9050-04-8
Inombolo yoBhaliso lwe-CDE:F20230000328
Ukuthobela i-Pharmacopoeia:I-ChP, i-USP-NF, i-EP, i-JP
Izithethantonye:I-calcium carboxymethylcellulose, i-calcium CMC, i-CMC-Ca, i-carmelose i-calcium
ABANYE:UTY7PDF93L
Inkangeleko:Umgubo omhlophe ukuya kotyheli-mhlophe okanye omhlophe qhwa, othambileyo emva kokomiswa
Ukunyibilika:Ayinyibiliki emanzini, i-acetone, utywala, kunye ne-toluene; idumba emanzini ukuze yenze i-suspension

Iimpawu eziphambili kunye neenzuzo

1. Indlela Ebalaseleyo Yokuqhekeka

Ayinyibiliki emanzini kodwa idumba ngokukhawulezaamaxesha amaninzi umthamo wayo wokuqalaxa udibana nemithombo yamanzi
Yenza uxinzelelo loomatshini oluqhekeza iipilisi ngokukhawuleza
Iqinisekisa ukubola ngokukhawuleza nangokupheleleyo ukuze ichithwe kakuhle iziyobisi
Isebenza kakuhle nakwiipilisi eziqinileyo apho ezinye izinto eziqhekekayo zisenokungasebenzi ngokwaneleyo

2. Isincedisi semisebenzi emininzi

Ukwahlukana:Umsebenzi oyintloko njenge-tablet disintegrant kwi-concentrations ye-0.5-15%
Isibopheleli:Isibopheleli esisebenzayo kwiinkqubo ze-granulation ezimanzi
Isinyibilikisi/Isizalisi:Ingasebenza njenge-tablet diluent
Uncedo lokuxhoma:Isetyenziswa njengesiqinisi sokumiswa ekulungiseleleni ngomlomo nangaphandle

3. Inzuzo engenaSodium

Ayinasodium – ilungele amayeza entliziyo kunye nezigulane ezine-sodium encinci
Ijongana neemfuno ezikhulayo zolawulo kunye nezigulana zefomyula ezinesodium ephantsi
Ihlangabezana neendlela zokwenza imveliso ecocekileyo neqonda impilo

4. Ukuhambelana kakuhle kwe-API

Isebenza ngakumbi kwiamayeza e-cephalosporin, kunye neempawu zokuphucula ukunyibilika ezibonisiweyo
Ulwakhiwo oluhle lwe-chelating lunceda iiklasi ezithile ze-API
Iyahambelana nezithako ezahlukeneyo ezisebenzayo eziquka: iPioglitazone HCl, iAminophylline, iBerberine HCl, iMilnacipran HCl, iCefixime, iNicorandil, kunye nezinye ezininzi.

5. Iimpawu Eziphezulu Zomzimba